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Together, these results imply that different myeloid leukemias, including APLs, share the same subset of cooperating mutations, and are consistent with a scenario whereby specific initiating mutations interact with a common pool of highly heterogeneous, yet phenotypically equivalent, cooperating mutations.
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Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver oncogenes are difficult to be uniquely defined.
Modeling and simulation of highly heterogeneous materials: Zohdi pioneered the computational analysis of particulate functionalized materials in multiphysical regimes.
TCA method was here developed with human kidney samples, as an example of highly heterogeneous organ.
HNSCC is a group of highly heterogeneous tumours.
Biological samples generally consist of highly heterogeneous cell populations.
In such highly regenerative species, the blastema consists of a heterogeneous pool of highly proliferative mesenchymal cells that gives rise to the large amount of new tissue in the regenerate (Knopf et al., 2011; Tu and Johnson, 2011).
As a result, the meta-analyses often pooled trials with highly heterogeneous acupuncture and control interventions14,23, which makes interpretation of their results very difficult.
The treatment of gastric cancer is challenging because of its highly heterogeneous etiology and clinical characteristics.
Second, when the ICD codes are accurate in defining an event, the clinical vagueness inherent in the description of the code itself may lead to a highly heterogeneous pool of clinical states represented by that code.
However, this method only permits analysis of the highly heterogeneous LIN−Kit+ population.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com