In the mid-1990s, a group in San Antonio developed the "Talairach Daemon", allowing electronic pooling of findings from brain mapping studies based on their coordinates in Talairach space.
The heterogeneity of study designs and the limited numeric outcome data prevented the statistical pooling of findings, so the findings are presented in narrative form, ie, in a table.
For fasting insulin, the standardized mean difference ES, adjusted for small sample bias, was calculated from each study in order to create a common metric for the pooling of findings [ 48].
The use of such protocols developed by CDISC or other appropriate sources during the conduct of clinical studies increases the likelihood of capture of complete and uniform data to enable robust analyses of DILI events, as well as the pooling of findings across trials.
12 Of the numerous systematic reviews of tinnitus treatments that have been published over recent years, many of them reach the conclusion that few high-quality trials are available for inclusion and for those trials that are included, a range of different outcome measures preclude the pooling of findings.
Given the different methods of reporting results for primary outcomes, i.e., FN and LS BMD, the standardized mean difference effect size (g), adjusted for small sample bias, was calculated from each study in order to create a common metric for the pooling of findings [ 62].
Correct scaling of the measurements enhances the comparability of results between studies and facilitates pooled analyses of findings, which is a natural step forward in our efforts to understand hormonal effects on disease risk and is the most efficient way to combine data resources and scientific expertise.
Pooling of the findings from diabetic participants across studies (n = 8,427 participants; 18% of total) revealed a significant positive association between LpPLA2 mass and CHD (RR 1.16 per SD [95% CI 1.05 1.28]), which was comparable to that observed in the larger sample without diabetes (5).
The pool of documented radiological findings is even more sparse as not more than a dozen cases could be abstracted from an Internet search of the radiology literature.
The larger pool of studies and positive findings among non-cancer patients suggest it is worthwhile to continue to develop and test such strategies for cancer-patient populations.
