Therefore, we propose our novel network-based enrichment as a procedure helping in formulating new hypotheses on the biological processes underlying a particular phenotype for which a pool of associated proteins is known.
In the pool of associated intron and exon sequences, these repeats occur between 2 and 87 times and are marginally AT rich (57.3%), but no correlation between repeat AT content and frequency was detected (supplementary table S6, Supplementary Material online).
Interestingly, the membrane kisses of tight junctions frequently extended down the apical-lateral membrane for over half a micron whenever there were pools of associating intracellular membranes.
We have refreshed and will continue to revise our pool of Associate Editors and Board Members so that we have more involvement from junior faculty.
For example, from Table 1 it is evident that for class I obesity (BMI ≥ 30), the available pool of savings associated with 15% temporary weight loss (i.e., 90% of the weight is re-gained over 10 years), is $49 billion over a 10-year period.
While total levels were similar, the pool of Munc18 associated to membranes was significantly increased in ASMko synaptosomes (Figure 4A,B).
To minimize false positives in the pool of SNVs associated with each child, only highly concordant SNVs were used (SNVs detected by all five pipelines).
SLY1 is a cytoplasmic protein but our findings suggest that it interacts with the ER exit sites anchored TANGO1, so is there a pool of SLY1 associated with ER exit sites where TANGO1 resides?
The existence of a pool of AhR associated to the plasma membrane was first suggested by the presence of the endogenous protein at the leading edge of migrating T-FGM AhR+/+ fibroblasts and by the location of the ectopic EYFP-AhR protein in lamellipodia of the plasma membrane of T-FGM AhR−/− fibroblasts.
A difference in actin organization relative to WT cells was also observed by live total internal reflection (TIRF) microscopy of TKO cells, co-expressing the calponin homology domain of utrophin fused to mCherry (CHUtr mCh) and CLC fused to GFP (CLC GFP), as there was a general increase in the pool of actin associated with clathrin spots.
Indeed, cell differentiation caused a measurable shift in the pool of lincRNAs associated with SCML2, suggesting that in addition to intrinsic binding preferences, cellular context may also determine which RNAs bind to SCML2 and, in turn, how its function and distribution on chromatin is affected by these interactions.
