Sentence examples for polymorphism and the predisposition of from inspiring English sources
Accumulating studies have reported that there is an association between the Ring finger protein 213 (RNF213) p.R4810K (rs112735431, c.14576G>A) single nucleotide polymorphism and the predisposition of moyamoya disease (MMD), intracranial major artery stenosis/occlusion (ICASO), quasi-moyamoya disease (quasi-MMD), and other vascular diseases.
A goal of the new postgenomic era is to uncover correlations between particular polymorphisms and the predisposition to develop certain diseases as a result of complex interaction of genetic, nutritional, and metabolic factors [ 2].
However, there are still controversies of the effect of TGFA polymorphism on the predisposition of this malformation [ 24- 35].
The importance of specific allelic polymorphisms in the predisposition of human beings to longevity or resistance to age-related disorders has been emphasized by studies of centenarians [3].
This finding was reinforced by recently published meta-analyses which suggest that PTPN22 C1858T polymorphism may contribute to the predisposition of the T1DM especially in populations of Europe and America.
To date, the predisposition of TREM-1 gene polymorphisms to sepsis has not been reported.
Our results support a potential role of the IL18 -607 C>A (rs1946518) and the IL18-1297 T>C (rs360719) gene polymorphisms in the predisposition to biopsy-proven GCA.
Given the limited study populations, more studies with large study population are suggested to further validate the relationship between GST polymorphisms and genetic predisposition to cataract, e.g., association of GSTT1 null polymorphism with cataract risk in Asian.
Via this mechanism, the polymorphism may constitute one of the genetic components underlying insulin secretion, and could explain the genetic predisposition of certain individuals to type 2 diabetes.
To estimate the contribution of 9 obesity-related polymorphisms and a genetic predisposition score (GPS) on anthropometric and biochemical variables before and after a weight loss intervention program in overweight/obese Spanish adolescents.
Similarly, gene polymorphisms and the Helicobacter pylori bacteria jointly cause ulcers and stomach cancers.
