In order to provide all of these attributes to emulsions, several excipients have to be used [ 3] such as surfactants, coemulsifiers, polymers, preservatives, emollients, and solubilizers.
One of the environmental contaminants and a famous estrogenic endocrine disruptor is the bisphenol A (BPA) which is used in the creation of polycarbonate plastic (e.g., water bottles, baby bottles) and epoxy resins (e.g., inside coating in metallic food cans) and as a non-polymer preservative to other plastics (Chitra, Latchoumycandane, & Mathur, 2002; Hernandez-Rodriguez et al., 2007).
The NOVADUR® system contains a poly d, l-lactide co-glycolide) intravitreal polymer matrix without a preservative, which slowly biodegrades to lactic acid and glycolic acid.
The drug concentration, pH, and addition of preservatives and/or polymers in Voriconazole in situ gelling formulations did not show any corneal damage as the corneal hydration value for all corneas remained in the normal range of 75%to80%0% (Table 3).
Avoid canned aloe vera gels as they usually contain synthetic polymers as gelling agents, chemical preservatives, and perfumes.
Preservatives have been widely used in wood preservation process, agriculture, chemical, and polymer technology to protect various products against decay by biodegradation [1].
Final polymer degradation products, phenolic antimicrobials and EDTA, are both commonly used as preservatives and are found on the FDA GRAS list.
Previously, our group has synthesized polymers chemically, incorporating various bifunctional and monofunctional bioactives; however, in this research the polymers hydrolyze into the phenols and EDTA, both of which are known preservatives and safe to use in consumer products.
The HEC placebo gel formulation contains 2.7% HEC as the gel-forming polymer, 0.85% sodium chloride for tonicity adjustment, 0.1% sorbic acid as a preservative, and sodium hydroxide q.s. to pH 4.4.
