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The ODMA monomer acts as a physical crosslinker, preventing polymer dissolution upon temperature reduction.
Polymer dissolution is complete within 48 h at both pH 5.0 or 7.4.
The polymer dissolution effect was related to the degree of unfolding of the polymer molecular chains and their entanglements.
Furthermore, acylation of triblock copolymers may allow for the design of bioerodible systems with control over degradation by polymer dissolution.
Drug release is affected by water imbibition, drug diffusion and polymer dissolution and is faster compared to 0.1 N HCl.
Polymer dissolution rates at the range of pressures studied were evaluated to quantify the dissolution kinetics for the polymer.
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Parametric studies were done to assess the impact of physical parameters – namely the concentration-dependent diffusion coefficient of water through the polymer, the dissolution rate constant of the polymer and the disentanglement threshold of the polymer – on the radial expansion of the tablet.
The release of polymer and dissolution of Si species and Ca2+ ions from the hybrids often reveal a large amount of information on the structure and bonding present between the constituents of the hybrid.
Tendency of the polymers for dissolution at relatively high amount of NaSS is attributed to the high electrical charges induced by NaSS units statically incorporated in the polymer chain as it was for the formation of soluble polyelectrolyte.
Amorphous polymers themselves are superior to semicrystalline polymers for the dissolution enhancement of the crystalline API in a medium containing pre-dissolved polymers.
Synergetic role of polymer blending on dissolution of amorphous solid dispersion was investigated.
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