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Nguyen, T. H. et al. A heparin-mimicking polymer conjugate stabilizes basic fibroblast growth factor.
Additionally, survival of tumour-bearing mice was strongly dependent on molecular weight and polymer conjugate architecture.
Furthermore, accumulation of this polymer conjugate in kidney was much lower compared with oxaliplatin.
IT-101 (Insert Therapeutics-101) is a linear, cyclodextrin-containing polymer conjugate of camptothecin (CPT).
The polymer conjugate with free ligands was toxic to the cells likely due to depletion of essential metal ions.
It was found that the polymer conjugate conformation depends on the antioxidant structure and degree of substitution.
Similar(19)
Bontempo, D. & Maynard, H. D. Streptavidin as a macroinitiator for polymerization: in situ protein-polymer conjugate formation.
The drug-polymer conjugate (mPEG-DXM) was freely water soluble at room temperature.
A systematic characterization method identified the leading sources of instability within the enzyme-polymer conjugate system.
Watanabe et al. also reported that folate-polymer conjugate can target the folate receptor of KB cells, with the IC50 of folate-polymer conjugate-coated liposomes being twofold lower than polymer liposomes [24].
When this drug-polymer conjugate reaches its desired destination, tumor environment converts into more active form.
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