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Although our panel study design was well powered to investigate associations with pollutants and interaction effects with stress and other time-varying characteristics, with only 50 participants it had little power to detect effect modification by sex, comorbidities, medications, and other time-invariant characteristics.
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To address potential synergistic effects among air pollutants, multivariate models with main effects for each pollutant and interaction effects for each pair of pollutants has been suggested [ 1, 21].
However, experimental studies of individual organic pollutants and their interactions with different organisms are decisive if there is to be a clear depiction about the interaction properties of the pollutant with diverse organisms and cell types.
The removal rates of three typical pollutants and their interactions with precipitation and underlying surfaces were identified.
The results of this study indicate that the surface properties of the particles, the chemical properties of the chemical pollutants, and the interactions between particles and pollutants play a major role in defining the biological effect of particle-pollutant complexes.
Mixed-effects models were used to assess effects of pollutants, SNPs, and interactions under recessive inheritance models using repeated measures.
Given that actual exposures are almost invariably to multiple pollutants, not to single pollutants, a strength of our approach is that we can potentially capture more of the effects of the pollutant mixture and interactions with weather conditions than the usual single-pollutant or two-pollutant models.
The possibility of a lag effect of each pollutant and the interaction of different pollutants were also examined.
This possible protective effect should be examined in further studies of gene environment interactions, which would focus on studying the effect of mixtures of air pollutants and their potential interaction with genetic susceptibility, particularly in pathways involved in DNA repair or xenobiotic metabolism.
On the first 7 days of incubation, zinc alone reduced the urease activity more significantly than any other pollutants and no significant interactions between PAH and HM were observed.
The environmental component usually consists of models describing the generation and transport of pollutants and their subsequent interactions with the ecosystem of the region(s).
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