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In addition to these organic pollutants, elemental pollutants, such as lead and mercury [ 7] also contribute to the pollutant burden and associated adverse physiological effects, sometimes acting in concert with organic pollutants [ 8].
The higher pollutant burden is considered to be at least an additional stressor facilitating cachexia [ 27] and/or indicates a transfer or mobilisation of such pollutants during starvation [ 28].
In each of these examples, the effect of the combination of insults (pollutant burden and other stressor) resulted in differences in tissue EDC burdens or enhanced susceptibility to the pollutants.
In addition, it acts as a promising mutual sample to indicate both the prenatal and maternal exposure, and it also contained relatively more pollutant burden than other tissues, hence easier to detect and quantify.
Thus exposure experienced by both cases and controls may be higher than estimated through the TRI, because such facilities also may contribute to the overall pollutant burden in the community.
From around the time of the Second World War, the nature of the pollutant burden within the environment, its distribution and effects have changed significantly, largely as a result of human activities and inventions.
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Aquatic organisms have played important roles as early warning and monitoring systems for pollutant burdens in our environment.
However, we observed no increasing gradient with increasing poverty, suggesting that segregation affects pollutant burdens in a manner independent of area-level poverty.
This is the first known study to assess broad geographic trends in CYP1A1 expression, stable carbon and nitrogen isotopes, and organic pollutant burdens in a threatened whale species.
The capacity of environmental pollutants to adversely affect the immune system and the importance of exposure during foetal development, are well known from studies of species exposed to heavy pollutant burdens (Martineau et al., 1988; De Swart et al., 1995; Dietert and Piepenbrink, 2006).
Our future work will re-examine potential effect modification of air pollution birth outcome relationships by individual and area-level SES factors in a larger population that includes births from several states with a broader range of pollutant burdens and neighborhood conditions.
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