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The highest number (123) of SU transcription factors was found in the naive subtype – perhaps this implies a requirement for this number in maintaining a transcriptional programme poised for commitment to one of several possible differentiated fates.
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Accordingly, we have suggested that EpiSCs may represent a primed state of pluripotency that is poised for lineage commitment (Nichols and Smith, 2009).
During muscle homeostasis, D3 is expressed in the satellite cells that are poised for myogenic commitment (Pax7Lo), wherein D3 expression does not simply reflect a secondary homeostatic regulation of this enzyme, but causes an intracellular attenuation of the TH signal compared to the Pax7Hi cells.
These bivalent marks are thought to keep developmentally important genes silenced, but poised for activation during lineage commitment [ 6].
But poised for what?
Zambia seemed poised for recovery.
He is poised for a breakthrough.
Vehicles and machines are poised for action.
Bono seems poised for more tech success.
"We are poised for progress," he said.
Another thought it was poised for collapse.
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