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Until now, the resulting concepts and strategies for engineering salinity stress tolerance in their majority targeted single genes in biochemical pathways, which represent end points of response cascades, but engineering of upstream master switches that regulate the activity of many downstream genes and proteins is increasingly attempted.
Functional MRI biomarkers of response described need careful validation, ideally against clinical outcome measures, before they can be adopted as established surrogate end points of response.
In this study, chemo-naive patients with advanced NSCLC were treated with SPI-77 at different dose levels, with the primary end points of response and toxicity, and the secondary end points of survival.
The use of the two largest lesions provided a high degree of concordance with the use of all reported lesions for the end points of response rate and time to progression.
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We performed a phase-II trial of RA in relapsed, sensitive SCLC with the primary end point of response rate.
Parametric analysis is done on the central point of alluvial valleys where the critical point of response under existence of sediments stands.
The smoothed frequency responses are shown to be connected with modal density, and, depending on the number of terms which are takem in the expansion, are capable of exhibiting influences of point of excitation, point of response, and participation of the various modes of vibration.
Pathological complete response is the most reliable end-point of response to neo-adjuvant treatment and hence was chosen in this study.
The imbalance of Th1 and Th2 phenotypes at the lymphocyte point of response may also explain our observations in addition to potential reprogramming of antigen-presenting cells.
Study treatment was planned to last 12 weeks (six cycles) at which time the primary efficacy end point of response rate was assessed.
The doses and scheduling of the taxanes vary between studies, but the end points of PSA response and response of measurable soft-tissue metastases were similar; the latter applies to only a minority of the patients enrolled on these studies.
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