This is well before an adaptive primary immune response expands to the point of effectiveness.
Which do you think is important, 'mortality reduction' or 'detection rate' from the point of effectiveness?
Primary end point of effectiveness of response was assessed after 24 weeks of treatment-free followup: HBeAg seroconversion (defined by the loss of HBeAg and the presence of anti-HBe antibody) and suppression of HBV DNA to levels below 100,000 copies per milliliter.
Secondary end point of effectiveness of response assessed after 24 weeks included the combined response (HBeAg seroconversion, the normalization of alanine aminotransferase levels, and the suppression of HBV DNA levels to below 100,000 copies per milliliter), HBsAg seroconversion (defined by the loss of HBsAg and the presence of anti-HBs antibody), and the histologic response.
There is evidence pointing towards some degree of effectiveness of resilience promotion programs, despite the poor operationalization of the construct and great heterogeneity in the studies.
Because there are only few reports on a long-term follow-up of patients who underwent adoptive T lymphocyte immune therapy without IL-2 injection, we assessed survival time on the basis of evidence-based medicine, to be the end points of the effectiveness of immunotherapy alone and immunotherapy combined with chemotherapy or radiotherapy.
Reviews summarized narratively do not provide point estimates of effectiveness.
However, in the policy setting, a point estimate of effectiveness provides insufficient information on which to base policy.
Moreover, the use of surrogate end points as outcomes of effectiveness has been extended to survival and even to the assessment of quality of life.
But he added that the whole point of comparative effectiveness was to move medical practice beyond the limits of such trials, by looking at a broader range of evidence that includes the actual experience of patients undergoing treatment.
