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Invariably they burn through much of their early-stage financing runway before working on their core product enough to secure the proof points necessary for follow-on investment rounds.
However, the applicability of malaria risk mapping to make predictions at spatial scales and time points necessary for effective health service planning and review depends largely on the amount and resolution of information available.
The revolution in catenane synthesis started in 1983 when Strasbourg chemist Jean-Pierre Sauvage recognized that the orthogonal arrangement of bidentate ligands in a tetrahedral CuI complex could be used to generate the crossing points necessary for catenane formation.[ 13c Template synthesis has been the basis for forming the vast majority of catenanes ever since (Sections 2 4).
All data points necessary for analysis including predictor variables and outcome data for the three clinical rules under investigation (Tables 1, 2 and 3) will be collected for all patients but treating clinicians will manage patients as per their usual practice.
For example, in two studies [ 61, 79], while drug users displayed more depressive symptoms than non-users according to the Center for Epidemiologic Studies Depression scale (CES-D), their scores did not reach the standard threshold of 16 points necessary for a diagnosis of depression.
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Moreover, it provides a reference point necessary for evaluation of one's ability in occupations and whether those can be transferred to entrepreneurship (Nanda and Sorensen, 2010).
Short has taken his time making this key move, a process no doubt brought into even sharper relief by Di Canio's 13-game reign - although that should be placed in context as Sunderland's owner remembered how "he came in and provided the fire that we needed to fight for the points necessary to stay in the league" last season.
Since at least two data points are necessary for the fitting, the effective half-life was calculated from the following measurement points: 24 h (2 h/4 h and 24 h), 48 h (24 h and 48 h), and 72 h (24 h, 48 h and 72 h).
The method is not wholly objective because two investigators may produce somewhat different maps whenever interpolation between data points is necessary for construction of the contours.
The double-quantum dephasing experiment can be combined with constant-time data sampling to compensate for relaxation effects, consequently only two experimental data points are necessary for a single distance measurement.
Detailed pharmacokinetic investigations of the PEGylated Au DENPs at extended time points are necessary for a complete understanding of the metabolism and biodistribution of the Au DENPs. Figure 9 Biodistribution of PEGylated Au DENPs in different organs.
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