The enzyme may be useful as an adjunct to central nervous system-directed therapies and could be used as a starting point for modifications designed to improve brain delivery.
There are the obligatory bass and treble settings with adjustable crossover points for sound modifications in different types of rooms.
Therefore, inhibitors 1 and 9 represent important starting points for synthetic modifications and development into more potent noncovalent inhibitors of PBPs that can target penicillin-resistant bacteria.
Some points for minor modifications: When I read the title my first impression was that the manuscript compares the promiscuity of drugs with respect to their release data, e.g. "do more recent drugs show more or less promiscuity than older drugs".
Cysteines have been used as attachment point for such modification, however, to be susceptible for chemical modification the involved thiol must be in its reduced form.
The single primary hydroxyl group at the C6″ position in tobramycin was chosen as a point of modification for the peptide tobramycin conjugate (Scheme 1, compound 4) due to its expected higher relative reactivity (compared to secondary hydroxyls).
In the past decade, significant discoveries in the plant volatile biosynthetic pathways have provided a starting point for their modification.
