Sentence examples for points for further optimization from inspiring English sources

We consider these achiral inhibitors highly suitable as starting points for further optimization.

The compounds 15 18 (MIC 11 29 μg/mL, 19 51 μM) can be used as starting points for further optimization.

Although the initial MESA development described here relied upon design-based methods, it is certainly possible that these functional designs may serve as starting points for further optimization using approaches such as directed evolution or computation-guided protein engineering.

In conclusion, using a novel α7/Ls-AChBP chimeric protein crystal structure we have successfully identified novel α7 receptor ligands that may serve as chemical starting points for further optimization.

Inhibitors 18 and 21 are also potent BMK1 inhibitors and possess favorable pharmacokinetic properties which enable their use as pharmacological probes of BMK1-dependent phenomena as well as starting points for further optimization efforts.

Following a virtual screening campaign the results of the experimental evaluation confirmed the protocol quality, while the two most active molecules which inhibited mPGES-1 in a cell-free mPGES-1 activity assay, compounds 6 and 7, may serve as promising starting points for further optimization.

This pre-optimized pulse then provides a good starting point for further optimization using a gradient-based method.

First, various homologs were compared to identify the most suitable starting point for further optimization.

This new scaffold can serve as a starting point for further optimization towards in vivo efficacy.

These results and compounds provide a starting point for further optimization, design, and synthesis of new antiviral agents for this (re)emerging disease.

Particularly, compound 13i showed better antifungal activity than the lead compound, which can be used as a good starting point for further optimization.