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Locating the target temperature points downstream of the flows that sweep boundary walls can help reduce the posedness of the governing matrix.
The addition of lactate increased recycling in many other points downstream of glucose entrance.
Intriguingly, this triplet has anchor points downstream of the TSS, and within the TSS itself.
Surprisingly, Tim-1 QGQ-expressing cells displayed enhanced tyrosine phosphorylation at early time points downstream of TCR and CD28 stimulation, compared with the effects of WT Tim-1.
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Shaft and tunnel spillways can carry away the water to a point downstream of the dam.
This vector QoI was broken into a set of scalar QoIs, each representing the density of NO at a specific point downstream of the shock, and sensitivities were calculated for each scalar QoI based on both measures of sensitivity.
P-Rex1 is highly expressed in human breast cancers with high ErbB2 and estrogen receptor expression and functions as a Rac-specific activator at a convergence point downstream of ErbB receptors and other growth factor receptors (Montero et al., 2011; 2013; Sosa et al., 2010).
The process of translation occurs at a nexus point downstream of a number of signal pathways and developmental processes.
There are also ways of bypassing phospho-Akt altogether, either by promoting signal transduction at a point downstream of Akt or by activating a parallel pathway(s) that can compensate for loss of PI3K/Akt signaling [24] [26].
When PGC-1α is knocked down by siRNA interference, the stimulatory effect of high glucose on VSMC proliferation and migration was restored even in presence of palmitic acid (Fig. 5), indicating that PGC-1α is an integration point downstream of various nutrient-dependent signals that regulate VSMC proliferation and migration.
Given our further observation that physiological leptin treatment failed to reconcile high fat diet- or age-induced detrimental effects in cardiomyocytes, the convergence between aging and obesity in cardiac contractile and intracellular Ca2+ defects as well as O2− accumulation likely occurs at a point downstream of or independent of leptin signaling.
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