The results show that the shape of subsequent yield surfaces and the "sharp corner" appearing at the front end of a yield surface are closely related to the tensile or compressive pre-loading direction and different yield point definitions.
For more-to-the-point definitions in link with neuroscience, and heuristic interpretations, we refer the interested reader to the very limpid article of Brown et al. [2] on the time-rescaling theorem.
Models with absolute-scale cut-point definitions (HI11 and HI15) resulted in negative associations closer to zero.
Comparison between these studies is difficult due to large differences in study design, inclusion criteria, biopsy-scoring methods, treatment strategies and end-point definitions.
The performance of prediction models varies in relation to different population strata, and obviously in relation to the clinical outcome or end-point definitions.
Discrepancies between reported and per-protocol end point definitions arose from the use of 'event' or 'failure', which affected time-to-event end points, such as PFS, EFS, time-to-failure (TTF), failure-free survival (FFS), and disease-free survival.
From NAD models containing these five HIs, those with relative-scale cut-point definitions (HI02, HI06, and HI10) showed similar positive associations and had lower confidence limits that were above or near zero.
These comparisons present the hazard of being potentially misleading because of fundamental "apples-to-oranges" comparisons secondary to differences between trials in patient populations, inclusion criteria, management algorithms, and end-point definitions [ 14].
Other strategies for anchor point definitions have thus included binding sites for clusters of transcription factors [ 17] or for specific transcription factors, like the enhancer associated protein p300 [ 14, 18, 19].
Response evaluation was performed by independent review of patients records and radiology reports by two investigators and classified in accordance with the Southwest Oncology Group response criteria and end point definitions (Green and Weiss, 1992).
