Only Mosse was ready to make an occasional hostile point, broadly echoing Emily's sister Charlotte's famous verdict on Austen's work ("a carefully fenced, highly cultivated garden" where Charlotte wanted "open country – fresh air"; an accurate portrait of "a commonplace face" where she wanted "a bright vivid physiognomy"), though tellingly not quoting it – too unsisterly?
The participants were elderly, but associations with end points were broadly similar to those observed (separately for CVD and diabetes) in younger populations (10, 12).
The age, gender and practice distribution of the samples at the various selection points were broadly representative of the baseline eligible population, although women aged 75 years and over were under-represented among clinic attenders (table 1).
Although responders did show some differences from non-responders, it is reassuring that the repeated measures analysis that uses data from all follow-up points gave broadly similar results to the intention to treat analyses.
"The fact that it's a medicine that's expensive really raises an issue, not just for this trial, but we tried to make the point more broadly".
The Bank of England's summary of business conditions, based on reports from regional agents, said "investment intentions had fallen since the EU referendum" and pointed to "broadly flat business investment over the next year".
He pointed to broadly positive ratings from Merrill Lynch, UBS and Cazenove, which said the insurer was trading at a significant discount to rivals and could be expected to outperform the sector.
"The latest indicators that we've had from surveys of industry and across the whole economy over the last two months are pointing in broadly the right direction," Trichet said in an interview with Europe-1 radio.
This new ITK will be made from several pixel and strip layers, and is designed to withstand the extreme radiation environment in close proximity to the HL-LHC interaction point which broadly speaking means an order of magnitude higher radiation hardness than the existing ID.
A summary of the changes in gene expression occurring at each time point are broadly summarized in Fig. 2, 3, and 4. The key findings are discussed below.
