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While the unadjusted class rank showed the median legacy improving their position relative to the median white non-legacy by 5.5 percentage points, adjusting for selection shows their position actually falls by 3.8 percentage points.
We also developed multivariable Cox proportional hazard models to assess the effects of aspirin on primary end points adjusting for age, hypertension, dyslipidemia, and history of smoking to see the robustness.
The efficacy of rituximab versus placebo was analysed using the Cochran Mantel–Haenszel test for categorical end points and analysis of variance (ANOVA) for continuous end points, adjusting for baseline stratification factors of rheumatoid factor (RF) status and region (USA vs non-USA).
We estimated that 180 participants per arm would provide at least 80% power to detect an effect size (difference in mean A1C change between intervention and control participants) of 0.5 percentage points, adjusting for correlation within PCP practices, and for a participant attrition rate during follow-up as high as 30%, applying a conventional significance threshold of P < 0.05 (16).
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Generalized linear models with repeated measures analysis of variance and univariate tests of variance were used to investigate changes in the dependent variables (as continuous traits) over time at each of the follow-up time points, adjusted for baseline values.
Table 4 presents the values for individual end points adjusted to year 2000 income levels.
Moreover, the proportion of participants who accurately perceived their CHD risk also significantly increased (+33 percentage points; adjusted p < .0001).0001
Table 2 gives HR with 95% CIs for all end points, adjusted for covariates as given in the table.
Individuals with poor performance in the Mini-Mental State Examination 9 were excluded from the study, being the cutoff points adjusted to education.
*Analyses with multiple imputation for missing baseline and follow-up data points adjusted for baseline measures of outcome and minimisation variables (practice deprivation and practice size).
Initially, the diagnosis of obesity was based on body mass index cut-off points, adjusted by sex and age, developed by Cole et al. [ 12].
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