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The displacement of the key battle point will be measured by the IMU.
The primary end point will be measured from the medical record audit, thus minimising attrition.
The patient outcomes at each time point will be measured for a specific patient by a specific staff member.
The primary time point will be measured at 14 weeks post-surgery, a time when typically patients would have completed the TOP rehabilitation and returned to their usual activities.
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A pressure tonometer will be placed at the site of each artery for a few seconds until a pressure waveform is recorded and the distance between the carotid-radial and carotid-femoral pulse points will be measured.
Study end points will be measures of insulin sensitivity (HOMA, SHBG and testosterone), potential breast cancer growth factors (IGF axis, leptin and adiponectin), inflammatory markers (C-reactive protein and sialic acid), oxidative stress marker (urinary F2 isoprostane), weight and body composition (waist/hip circumference, fat free and total fat mass).
Additionally, employment status (self-constructed items; time points T0 – T4) and days of incapacity to work (measurement based on the DEGS [ 46]; time points T1 – T4) will be measured as secondary outcomes.
The place where the patient stops will also be marked with tape, and the distance between the two points marked will be measured.
At each of these time points, weight will be measured using an electronic calibrated scale (Seca 876, Chino, CA) and rounded to the nearest 0.1 kg with participants wearing light clothing and no shoes.
Quality of life, i.e. functional health and well-being from the patient's point of view, will be measured by means of the 12-item Short-Form Health Survey (SF-12), a validated subset of the generic health status questionnaire SF-36 [ 39, 40].
In order to do this, sub-domains of the care process from a patient, caregiver and professional point of view will be measured.
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