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Avise [ 35] proposed that deep coalescence of polyphyletically distributed lineages would point to incomplete lineage sorting, whereas shallow genealogical patterns would be caused by recent gene flow.
We investigated a large control population and the apparent finding of a large 3p14.1p13 deletion in this cohort affecting FOXP1 and further genes illustrates the difficulties to assess the significance of rare mutational events in extremely heterogeneous diseases and may point to incomplete penetrance.
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Interestingly, in the postnatal cortex of the Nogo-A KO mice, we did not detect any major abnormalities, although a surprisingly high interindividual variability in the cell density of layers II IV neurons was observed, perhaps pointing to incomplete compensatory mechanisms (data not shown).
In addition, the data point to an incomplete overlap between eIF4E domains involved in translation and proposed VPg-binding, which suggests that the purpose of any protein-protein interaction may not be exclusively to support PSbMV RNA translation.
Finally, approximately 400 genes are differentially regulated between white and opaque cells; although a few of these genes make conceptual sense (for example some mating genes are upregulated in opaque cells), most do not and, instead, point to our incomplete understanding of the fundamental differences between these two types of cells [for reviews see 24], [25].
This points to an incomplete metabolic shift in the newly formed heterocysts, related to both the central carbon and nitrogen metabolism.
This points to the incomplete nature of reporting in the clinical study reports and the important role of Summary Basis of Approval information.
However, elp6 mop2 RP40p::gam appeared delayed in their development, when compared to parental lines, indicating synergistic interaction between γ-toxin and Elongator, which points to an incomplete overlap of activities of these genetic traits.
7 This indicates that variations in oxytocin levels do not underlie the deficit in social recognition in AD and points to our incomplete understanding of the neural circuitries responsible for social recognition.
Any uneven distribution of molecules in the library at this point, whether due to incomplete mixing or DNA-DNA interactions assisted by cations [ 36], could lead to differences in the molecules loaded onto a lane.
As our reference list is necessarily incomplete, we also point to the surveys [8, 27] as trailheads for algorithms and theory respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com