Sentence examples for point substantial from inspiring English sources

These data also suggest that once a patient progresses to a certain level of CD4 depletion, it may not be as critical for how long they have been at that level, perhaps because at this point, substantial immunological damage has already occurred.

With this calibration point, substantial over-dispersion was observed for all analyzed divergence time estimates, so these results are likely to be a branch-length-related artifact (see above).

In all four countries the decade of fastest growth was the 1960s, with the difference between the 1960s and the decade with the second-fastest growth greatest for France and Italy (in excess of two percentage points), substantial for the United States (0.8 percentage points), and quite small for the UK (OECD statistics).

By the 8-day time-point, substantial differences in overall cell density were observed at the macroscopic level.

The results point towards substantial differences in turnover frequencies between the zeolite aggregates, revealing significant intraparticle heterogeneities in Brønsted reactivity.

"The point of substantial discounting is still valid," he said.

Most of this government's immediate predecessors have turned to the IMF at some point, receiving substantial sums in six of the 14 years between 1989 and 2002.

One of the consequences of only providing support at the point of substantial or critical risk is that by the time people reach that stage their needs are usually urgent, complex and costly.

Beyond this point, no substantial improvement was achieved.

Twin studies of behavior problems in childhood point to substantial genetic influence.

These concerns point to substantial issues in the methodology of the social sciences.