Sentence examples for point of mutations from inspiring English sources

We further find that the D23 K28 salt-bridge, a major feature of the Aβ40 fibrils and a focal point of mutations linked to early onset Alzheimer's disease, is not detectable in the small oligomers.

Contingency genes seem to have hot point of mutation that could be caused by their instability due to longer HPN and functional limitation under a particular niche.

For each mutation we selected a sequencing primer about 50 300 bp away from the point of mutation.

Five of the seven indels within SSRs with unit repeat of seven and eight nucleotides caused frameshift mutations resulting in altered amino acids from the point of mutation and premature truncation likely producing an altered or non-functional protein.

If we still cannot find the mutation point, in order to avoid falling into the search dilemma, set the sub-line point of the mutation point as (x p, 0); it will be directly removed in the follow-up discrimination.

Post-translational modifications are often investigated by ablating or mimicking them with the use of point mutations of modification sites.

Second, burden analyses revealed a high frequency of point mutations of SHANK3 in ASD cases [ 25, 26].

Heterozygous loss-of-function point mutations of miRNA genes are associated with several human congenital disorders1,2,3,4,5, but neomorphic (gain-of-new-function) mutations in miRNAs due to nucleotide substitutions have not been reported.

Cancer genes are affected by different types of point mutations and of chromosomal alterations.

For proteins that have evolved by the sequential accumulation of point mutations, most of those mutations must work well in many different contexts.

Comparison of proportions of point mutations between groups was done by chi-square test.