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This is well before an adaptive primary immune response expands to the point of effectiveness.
Which do you think is important, 'mortality reduction' or 'detection rate' from the point of effectiveness?
Primary end point of effectiveness of response was assessed after 24 weeks of treatment-free followup: HBeAg seroconversion (defined by the loss of HBeAg and the presence of anti-HBe antibody) and suppression of HBV DNA to levels below 100,000 copies per milliliter.
Secondary end point of effectiveness of response assessed after 24 weeks included the combined response (HBeAg seroconversion, the normalization of alanine aminotransferase levels, and the suppression of HBV DNA levels to below 100,000 copies per milliliter), HBsAg seroconversion (defined by the loss of HBsAg and the presence of anti-HBs antibody), and the histologic response.
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Despite the dangerous implications from a methodological point of view, the use of surrogate end points of effectiveness is a quite diffuse attitude, that is rapidly increasing in both clinical research and daily clinical practice.
There is evidence pointing towards some degree of effectiveness of resilience promotion programs, despite the poor operationalization of the construct and great heterogeneity in the studies.
Reviews summarized narratively do not provide point estimates of effectiveness.
However, in the policy setting, a point estimate of effectiveness provides insufficient information on which to base policy.
But he added that the whole point of comparative effectiveness was to move medical practice beyond the limits of such trials, by looking at a broader range of evidence that includes the actual experience of patients undergoing treatment.
The point of maximal effectiveness is found to correspond to a maximal thermal power density and thus to the minimal volume required for obtaining that effectiveness.
The point of maximal effectiveness is found to correspond to a maximal thermal power density and thus to the minimal volume required for obtaining a given effectiveness.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com