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By placing farmers as the starting point of disease surveillance, we contend that farmer-based syndromic disease surveillance holds potential to overcome the current limitations of conventional disease surveillance, and demonstrate its relevance for aquaculture, particularly in resource constrained environments.
It is also possible that the timing and point of disease introduction into YNP could account for these differences.
Disease duration was defined as the time in day between the clinical onset of disease and the clinical end point of disease.
Lithium was administered starting at 67 days of age until the end point of disease.
Nonetheless, included patients could be followed-up during the study period up to the point of disease progression.
Most often patients are allowed to switch to the new therapy at the point of disease progression.
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The results were analysed for the end point of disease-free and disease-specific survival.
The results were analysed for the end point of disease-free and overall survival.
Events used for the analysis of the end point of disease-free survival included local, regional, and contralateral breast cancer or distant breast cancer recurrence.
Previous work by the ACCENT group (Sargent et al, 2009) demonstrated that for the end point of disease-free survival, a time-varying treatment effect was present.
Although the primary end point of disease-free survival (DFS) was not met in the overall patient population, prospective subgroup analyses showed that ZOL significantly improved invasive DFS by 25% [hazard ratio (HR) = 0.75; P = 0.02] and overall survival (OS) by 26% (HR = 0.74; P = 0.04) in women who were more than 5 years postmenopausal at study entry (n = 1041) [ 1].
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