A variety of analyses linking model variables (e.g. scale and shape parameters from the Weibull distributions) to incidence, recurrence and prevalence are presented in Appendix II, see Additional file 2. This Appendix also contains a series of simulations, each with n = 25 replications showing the effect on point prevalence of alteration to various model parameters.
Although the results of our study point to alterations in gene expression of NMDA receptor subunits, further studies are warranted to elucidate the precise nature of the glutamatergic hypofunction in schizophrenia.
Both approaches, BAC mapping and loss of heterozygosity, point to alterations on canine chromosome 11, in the region equivalent to human chromosome 9p21 which is commonly deleted in human tumours [ 10] and contains the genes CDKN2B and CDKN2A.
From a systems biology point of view, alterations (e.g., mutations) in the genes coding for the "hub" protein would not be advantageous as they might lead to partial or complete collapse of the network.
The underlying causes of these changes are not fully understood but point to alterations in assembly of the machinery for T cell activation.
Similarly, candidate genes and functional imaging abnormalities in ADHD point to alterations in areas of the brain rich in dopaminergic/noradrenergic innervations.
Several sources of data now point to alterations in neural connectivity as a key factor in understanding the visuospatial, and likely numerical, cognitive impairments exhibited by individuals with chromosome 22q11.2 deletion syndrome.
Previous reports that examined the early events in the host following Leishmania infection pointed to alteration in the translocation of transcription factors such as AP-1 and NF-κB in response to agonists [4], [24].
Indeed, due to the melting point and boiling point of water, aqueous alteration and thermal alteration are intimately related.
For instance, the strong increase of S-adenosyl-methionine (SAM, Supplementary Figure S2), S-adenosyl-homocysteine (SAH) and cystathionine pointed to alterations of the methionine/cysteine metabolism, possibly to replenish the redox buffer GSH.
Nonhomologous substitution of a nonpolar hydrophobic amino acid, isoleucine, with the positively charged (polar) hydrophilic amino acid, arginine (I223R), seems to be a key point in alteration of the NA cavity.
