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Actually, the least core method shrinks the core space simultaneously from each side of boundary until a single point (imputation) is achieved.
Validation of the data point imputation.
In case of loss to follow-up or withdrawal resulting in missing data, these values were handled by the method of linear trend at point imputation.
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The results suggested that for the RECORD study the missing QoL scores could be imputed using assessments close to the point of imputation.
It is pertinent to note at this point that imputation using chained equations does not require the variables to be imputed in a specific order.
For each missing data point, five imputation values were generated and the mean was calculated [ 19].
In general, for the RECORD trial methods involving QoL scores surrounding (and in particular those after) the point of imputation were the most accurate in terms of bias and at preserving the variance.
In this study, we use local average of two neighboring points for imputation which is simple and fast.
Summary statistics are calculated for safety and immunogenicity end points without imputation for missing data.
Table 1 shows the mean scores at each of these time points (after imputation) for the four interventions groups, along with the mean QALY gain (over the two year trial period).
We will also test the sensitivity of our results to a 90% cut-off point for adherence, imputation of missing data using multiple imputation 28 and method of analysis (fixed-effect vs random-effect meta-analysis).
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