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Compounds affecting mitochondrial function and structural integrity by different mechanism would likely change the MMP, making this measure a suitable comprehensive first end point for screening.
The cutoff point for screening for diabetes with the highest sum of sensitivity and specificity in our data was an A1C level of 5.8%.
The best cutoff point for screening depression in our study (≥8) was lower than the cutoff point recommended for screening MDE among those studies performed outside the postpartum period [ 34- 36].
First, current guidelines do not yet specify "normal" values and evidence is accumulating that the "optimal" cutoff point for screening for asthma will not necessarily be suitable for other populations.
The most common time point for screening in both diseases was day 100, followed closely by day 365.
As a cut point the median value of SOC could not be considered a generalized recommended cut point for screening individuals.
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Cell death has been successfully employed as an end-point for screening a cDNA library in search of protein inhibitors of Caspases, where cDNA clones that rescued yeast from a Caspase-mediated lethality were identified [8].
Evidently, since we identified these new targets in a gene expression study, it still needs to be determined if the changes in RNA levels result in changes at the serum protein level that exceed maternal background levels at a time point suitable for screening.
The CHQ [ 23] is a 12-question, 2-reverse questions, 0-1-point questionnaire for screening "minor psychiatric disorders" such as anxiety disorder.
Based on evidence that a variety of chemicals, especially EDCs, may be contributing to the risk of breast cancer, we designed the HIA-BC to begin addressing the lack of relevant toxicity data by proposing end points useful for screening chemicals for their ability to alter biological processes related to breast cancer.
Outcomes of both infection and active disease were identified at the point of screening for infection after exposure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com