Biomarkers in osteoarthritis can be categorised using the five-point burden of disease, investigative, prognostic, efficacy of intervention and diagnostic (BIPED) classification scheme, which was developed by the Osteoarthritis Biomarkers Network with the aim of providing a common framework for communication in the field.
Pieces of entertainment become public causes and punditical talking points, burdened with absurdly heavy expectations and outsize significance.
Federer, not Murray, seemed to be the one always pushing, even straining, to keep pace, and perhaps it was that point-in, point-out burden that explains why this match — rare in an age of collegiality at the top — developed a genuine edge: Oaths and dark looks included.
Since that point, the burden on Her Majesty has eased.
At that point, the burden shifts to the employer to offer a "legitimate, nondiscriminatory reason" that explains the action.
Since that point, the burden on Her Majesty has been lessened – no speech after 2005 has totalled more than 1,000 words.
What made a difference to me over the years was that unlike my assuming the starting point and burden of issue based photography, I had started to recognize my expectations from photography more clearly and, more importantly, the position that I wanted to take.
This raises another point: the burden of welcoming Kerry's principles as something in line with Egypt's vision falls on the shoulders of the only current Arab member of the Security Council, and not just on European, Asian, and African states.
However, at this later time point, the burden of MAAΔ lprG in the lungs exhibited a significant reduction compared to that of the wild-type MAA strain).
There was no significant increase in the point mutation burden on deep sequencing of muscle mitochondrial DNA from SPG7 patients, with similar levels to age-matched controls and OPA1 patients, but significantly lower than in POLG patients (who are known to have a proofread-deficient mitochondrial DNA polymerase).
