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The absorbance values of ITF2357-treated groups were normalized to the control group at each time point analyzed.
Results are expressed as mean ± standard deviation (SD) from at least 3 independent experiments with each experimental point analyzed in triplicates.
To avoid bias, we only included patients who did not experience relapse, died, or were treated with SCT until the time point analyzed.
RSV F and RSV N were found to colocalize as early as 6 hpi and remained closely associated at every time point analyzed (Supplementary Fig. 3b).
A significant decrease in state 3 respiration was observed in every time point analyzed (LPS 6 h: 20%, P<0.05).
PGC-1α and mtTFA expression significantly increased in every time point analyzed, and mitochondrial mass was increased by 20% (P<0.05) at 24 h.
After grading individual brain regions for each mouse, averaged values for each time point analyzed (1 mpi (n = 3), 3 mpi (n = 2), 5 mpi (n = 3), and 9 mpi (n = 3)) were used to generate heat maps using the in-house software to graphically show distribution of pTDP-43 pathology based on a scale-color system71.
The primary end point analyzed was progression free survival.
In contrast, the pre-treatment of mice with imatinib did not affect the uptake of the radiopeptide, independent of the organ or time point analyzed (Figure 1B).
Control cultures were treated with vehicle (0.01% ethanol) for the longest time point analyzed (48 hours).
Therefore, lack of effect on neutrophil migration could be due to late time point analyzed.
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