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Trapezius activity may alternatively function as a marker of parallel pain-inducing activation responses, such as localized trigger point activity [ 8, 36, 64].
Chronic low back pain associated with myofascial trigger point activity has been historically refractory to conventional treatment (Pain Research and Management 7 (2002) 81).
For each organ, TACs were uncorrected for decay and residence times were computed as the trapezoidal sum of the TAC with the assumption that, after the last time point, activity decreased only by physical decay (i.e. no biological clearance after the last time point).
Of the 26 activator hits identified by the three-stage algorithm, the curve class method placed 15 in curve class 1 (full sigmoidal response profiles), 8 in curve class 2 (partial response profiles with one asymptote), and 1 compound each into curve classes 3 (single point activity), 4 (inactive) and 5 (undefined).
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Individual input functions were corrected for injected activity and aligned by the point of peak activity.
In the MnSOD lines, at later time points activity was increased at all hours of the day to the extent that sleep was nearly eliminated.
The resulting stable (fixed-point) activity pattern s ∞ is the circuit's phenotype.
End-point activity data from a single cell line may give only limited information on a compound's biological response.
Also throughout this work, we disregarded the phenotypes of circuits that attained no stable fixed-point activity pattern, as in previous studies [ 11].
Other curves and subclasses show either single-point activity (class 3) or have lower efficacies and R values (30 80% and < 0.9, respectively) and hence are associated with inconclusive activity.
A physical activity data analysis tool (ActiSCi, Suffolk, UK) was used to derive wear time, apply cut-point activity categories and undertake reintegration of epoch lengths (15 60 s).
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