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Noting the wide spectrum of potencies of different cofactors at saturation, Pcof, we propose a simple model in which cofactors bound in the ATP pocket shift an equilibrium between an inactive and an active conformation of Ire1.
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It started with solitary walks to the corner of Franklin Avenue and Eastern Parkway, where Maynard would stand, hands in his pockets, shifting his weight from right foot to left, whispering to himself for hours.
As discussed above, there are two pockets of residues in the crystal structure that accommodate the hexyl tail of covalent-orlistat in conformation I and hydrolyzed orlistat in conformation II and they are called short-chain pocket and shift pocket, respectively.
He put his hands in his pockets and shifted a little on his uneven legs.
There is an extraordinary moment when the platform darkens and pocket flashlights suggest shifting star patterns in the night sky.
Jeff Garcia had been bobbing up and down in the pocket all night, shifting his weight, looking for safety valves, until receiver Terrell Owens finally broke free of a web of blue jerseys in the 49ers' final drive of the night.
There's also lots of Western mythology, including Mitch Miller's orchestra-and-chorus take on "Yellow Rose of Texas" and multiple versions of the pocket epic "The Shifting Whispering Sands".
TodayTix faces an stodgy market and established players with deep pockets, but the shift to mobile is on its side.
"What are you doing?" I grabbed at her back pocket, but she shifted away.
He had notes on some sheets of yellow pad paper in his inside coat pocket, which kept shifting into view across his tie.
The tight fit of the sugar moiety into this pocket would prevent a shift in the position of the mannose moiety, in order to prevent steric hindrance with this carbonyl group.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com