Sentence examples for pocket alter from inspiring English sources

Moreover, mutations in the putative NADH-binding pocket alter several aspects of Edc3 function in yeast and human cells, including subcellular localization, P-body formation, and the control of mRNA degradation.

Second, we see a binding pocket altered in size and hydrophobicity.

Changing one amino acid from valine to isoleucine in the fifth transmembrane domain, which is thought to contribute to the shape of the pocket, alters the receptor protein in such a way that heptanol, instead of octanol, produces the greatest effect.

Mylan's latest announcement – that it would offer various new pricing concessions to families on lower incomes and those who have to pay out of pocket, cannot alter this stark fact.

Small amino acid substitutions within this alcohol binding pocket markedly alter the pharmacology of alcohol inhibition of L1 adhesion (Dou et al., 2011).

Amino acid substitutions that affect the opsin's retinal chromophore binding pocket can alter the pigment's absorbance spectrum, generating variation in spectral sensitivity [ 36, 37].

We anticipate that future work will help identify how critical somatic mutations in pocket regions alter protein function in cancer, including protein-protein interactions and drug binding.

However, it has been debated whether mutations in the protein pocket regions alter protein functions through the ligand-independent mechanisms [ 26].

Thus, interference with this domain's conformation and relative position within the receptor molecule seems a plausible mechanism by which the autoantibodies could hinder the access of ligands to the binding pocked and/or induce distortions of the ligand binding pocket that alter its ligand binding properties and/or mimic the effects of orthosteric agonist binding (Cherezov et al., 2007).

A change in a single amino acid can change the form of the pocket, thus altering the chemicals that fit into the pocket.

The activity of all of the mutated enzymes with non-specific substrates indicates that the substrate binding pocket is altered and has become flexible toward other substrates after mutation.