Exact(14)
Vaccine development and testing may be accelerated by use of animal models, such as the guinea pig keratoconjunctivitis or murine pneumonia models.
Previously, the reduction of atelectasis formation by the appliance of PEEP was correlated to greater bacterial clearance in porcine pneumonia models [11, 12].
This inoculum is consistent with those used in other published intranasal staphylococcal pneumonia models [10].
The α-hemolysin gene, Hla, is a critical virulence factor in cellulitis, mastitits, and pneumonia models of S. aureus infection [49], [50].
No difference in virulence was detected when comparing two prevalent CA-MRSA strains, LAC (USA300 lineage) and MW2 (USA400 lineage), to their respective isogenic PVL knockout mutants in several mouse models, including subcutaneous abscess, sepsis and pneumonia models [10] [13].
Bubeck Wardenburg et al. [11], [12] found no contribution of PVL to pathogenesis in C57BL6 and BALB/c mouse pneumonia models using wild-type CA-MRSA and isogenic Δpvl mutant strains.
Similar(46)
We used a porcine pneumonia model with the bacterium Pseudomonas (P).
We investigated the serum proteomic changes and potential biomarkers in an RSV-infected mouse pneumonia model treated with QFOL.
However, a pneumonia model without large systemic effects might have increased the possibility to study specific pulmonary effects of the ventilator intervention.
Eighteen BALB/c mice were randomly divided into three groups: RSV pneumonia model group (M), QFOL-treated group (Q) and the control group (C).
The present study was designed to examine innate phagocyte mediated immune mechanisms using a previously described murine S. aureus Newman pneumonia model.
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