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Acanthamoeba polyphaga mimivirus (APMV), the largest known virus, has been studied as a putative pneumonia agent, especially in hospital environments.
Moreover, although some authors suggest that mimivirus is a not frequent pneumonia agent (4 ), mimivirus has been isolated from a human with pneumonia (3 ).
Mimiviridae, the newest family in this group, has been researched as a putative pneumonia agent and found in different biomes worldwide (3, 5 – 9 ).
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Mimiviruses have been considered putative emerging pneumonia agents.
Herein, when conducting a large study of pneumonia agents in patients with ventilator-associated pneumonia, we were surprised to identify DNA from food plants and tobacco that had been inhaled by patients undergoing mechanical ventilation in the ICU.
All of these samples were previously tested for other pneumonia agents (4 ).
Streptococcus pneumoniae, a causative agent of pneumonia, meningitis, otitis media and bacteremia causes significant morbidity and mortality worldwide.
The other important species for public health is Chlamydia pneumoniae, a causative agent of pneumoniae, which has also been associated with a number of chronic diseases such as atherosclerosis, adult-onset asthma and Alzheimer's disease [ 4].
The goal of our current study is to understand the impact of chronological aging on innate immune responses to a secondary, post viral infection with Streptococcus pneumoniae, a causative agent of bacterial pneumonia.
The role of Streptococcus pneumoniae as an agent of septicemia, pneumonia, and meningitis is well known (1, 2 ).
Arguments supporting a pathogenic role are that Chlamydia pneumoniae, a well-recognized agent of pneumonia, was shown to infect free-living amoebae and that another member of the Chlamydiales, Simkania negevensis, which has 88% homology with Parachlamydia acanthamoebae, has caused pneumonia in adults and acute bronchiolitis in infants.
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