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In CYP2D6*Poor Metaboliser (PM) Model 2: the PM group (classified as stated) is compared with individuals who carried two copies of the wild-type allele (EM) at all SNPs (common homozygotes).
For example, the genes in the complement system were significantly regulated by PM in both the control (PM group) and the asthma animals (PM and OVA group).
Patients who had definite M and TTH were classified into the M group, and those who had PM and TTH were classified in the PM group.
In contrast, the corresponding duration of effect for these endpoints was systematically longer in the PM group (from 25to2828 h for the PM group vs. from 13 to 16 h for the EM group) (see Table 2 for details).
The percentage of non-responders was significantly higher in the PM group (46.7%) compared with the EM group (21.6%; p=0.005).
5 00 pm -‐ 8 30 pm Group Dinner: Tilden Park: at Mineral Springs Picnic Area - Bus pick up in front of Banatao (on Hearst avenue) at 5pm.
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Myositis-associated antibody, anti-SSA and myositis-specific antibody, anti-Jo1, were significantly less present in the SSc-PM group compared with the PM groups (Table 1).
SSc or myositis-specific antibodies were nearly absent in the SSc-PM group.
Similarly, in livers from the WT-PM group, we noted a clear trend toward a decrease in levels of phosphorylated AKT and phosphorylated IRS1 at Tyr 612, which was not observed in the CCR2-PM group.
SSc-specific autoantibodies (anticentromere and antitopoisomerase 1), were nearly absent in the SSc-PM group and present in 19% and 22% of the SSc patients.
The median modified Rodnan skincore (mRSS) was 6 (IQR, 5 to 11) in the SSc-PM group and 7 (IQR, 4 to 12) in the SSc group (Table 2).
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