Exact(5)
Hence, the PM is a useful inactive ingredient to produce various types of control-released system of insulin by making just a few changes in PM content of the formulation.
Effect of SMase treatment of human fibroblasts on amount of cell surface binding of I-PFO* (A) and PM content of SM and ceramide (B D).
Of note, epidemiological studies have revealed remarkable associations between PM content in ambient air and increased rates of respiratory disease in susceptible populations (Dockery et al. 1993; Pope et al. 1995).
The PM content of GLUT4 after insulin stimulation was drastically decreased in Axin- or TNKS-knockdown cells compared to adipocytes expressing control siRNA, whereas the overall expression of GLUT4 was not affected.
Organic PM content, including polycyclic aromatic hydrocarbons, quinones, and endotoxin, were not measured in the present study, although they can also trigger the generation of reactive oxygen species, once inhaled, through metabolism and the induction of inflammation (Ayres et al. 2008).
Similar(55)
The cost, Braked-specific fuel consumption (BSFC), and hydrocarbon (HC), nitrogen oxides (NOx), carbon monoxide (CO) and particulate matter (PM) contents were tested.
PM endotoxin content was not related to traffic density, with the highest concentrations observed at the high-traffic road tunnel (HIA) and the low-traffic Munich (MGH) background sites.
The identification of additional compounds that target PS lipid trafficking is now required to validate whether reducing PM PS content is a viable strategy to therapeutically modify K-Ras signaling.
Both transition metals (Cu, Zn, Fe) and quinones have been implicated in HOOH formation from PM. Zn and Fe were identified via correlation between HOOH production and PM metal content; however, many trace metals and quinones are covariate, which confounds identifying the redox-active species responsible for ROS generation.
In a study of cardiorespiratory admissions in children and elderly there were no observed associations between PM salt content and admissions, and it was suggested that salt could either act as a proxy of cleaner air (sea salt) or road dust (road salt) [ 29].
This demonstrates that PM catalytic metal content explained much of the intrinsic capacity of these samples to catalyze damaging oxidation reactions.
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