Our aim was to test the hypothesis that the prevention of PLM phosphorylation in a PLM3SA knock-in mouse (in which PLM has been rendered unphosphorylatable) will exacerbate cardiac hypertrophy and cellular Na overload.
The design and implementation of a PLM solution in a cross-company environment is a complex and labour intensive operation, which is often coupled with a Business Process Re-engineering (BPR) project to better deploy technologies as well as methodologies and to target the system implementation on the real company needs.
This combination of slightly increased α1 and decreased PLM resulted in a significant decrease in the PLM/α1 ratio.
Binding of the tetrapeptides, and of the QRATKM and RRATKM PLMs results in a significant displacement of the backbone in the 70 loop away from the active site (Figure 7B).
In an attempt to address this deficiency of traditional systems, this paper proposes and explores a novel model of product lifecycle management (PLM) in which instead of studying engineering activities exclusively with respect to a temporal variable, the processes are deliberately managed to form closed loops of two or more activities with respect to two independent dimensions: time and rigidity.
Confirming previous results, we found this PLM in both A. thaliana and O. sativa genomes in a preferential position 32 bases upstream of the TSS and strictly located within the [-39, -26] region.
In the introduction to this paper, we raise the possibility that the hypophosphorylation of PLM in the hypertrophied heart, as confirmed in this study, may simply be a bystander effect reporting on the prevailing state of the β-adrenergic signalling pathway without causally affecting the progression of the disease.
After surviving an assassination attempt in Texas, Flores Magón moved with the rest of the group to St .Louis, Missouri, where they formally established the Mexican Liberal Party (Partido Liberal Mexicano; PLM) in 1905 and resumed publication of Regeneracíon.
The requirements for the interoperability of semantics and knowledge have become increasingly important in Product Lifecycle Management (PLM), in the drive towards knowledge-driven decision support in the manufacturing industry.
The implication of Plm in cancer invasion and metastasis has focused on the Plm activation by urokinase-type Plg activator (uPA) through cleaving Lys580-Val581 and releasing the serine protease, i.e., Plm light chain [19].
