Sentence examples for plethora of substrates from inspiring English sources

Different CDK-cyclin complexes phosphorylate a plethora of substrates at the key G1-to-S and G2-to-M transition points, triggering the onset of DNA replication and mitosis, respectively.

Glycolysis is presented as the "selfish" pathway used for cellular proliferation, providing both the metabolic precursors and the energy required for biosynthetic purposes, in the context of a plethora of substrates.

Upon activation by DSBs, ATM phosphorylates a plethora of substrates implicated in cell cycle arrest, DNA processing and repair, chromatin remodeling, transcription and apoptosis.

These apoptotic pathways converge in the activation of executioner caspases, which proteolyze a plethora of substrates ultimately leading to the death of the cell [ 3].

As Fbxw7 regulates a plethora of substrates, we selected for analysis those known to be oncoproteins or involved in intestinal development or homoeostasis.

Often times, the current generation of pan/multi-targeted drugs like Aurora A, Cdk1 or Plk inhibitors show lack of activity, specificity and increased toxicity, especially if the targeted kinase is regulating a plethora of substrates.

Just as gene-sequence studies have revealed many putative enzymes with unknown substrates (orphan enzymes), metabolomic studies are revealing a plethora of orphan substrates, which makes the need for rational approaches to identifying the enzymes involved in their formation and breakdown a pressing concern.

The binding to various substrate-adaptor proteins at the N-terminal domain enables CUL3-RBX1 to appropriately ubiquitylate a plethora of cellular substrates (Wee et al, 2005; Harper & Tan, 2012).

The plethora of biological substrates, receptors and pathways for 5-HT are candidates to mediate not only the therapeutic actions of SSRIs, but also their side effects.

Moreover, Fernández-Gómez et al. [ 75] showed that TPOMW microbiota possess the ability to oxidize plethora of C substrates.

Erk1 and Erk2 boast a plethora of known substrates [ 13] and very likely more remain to be detected.