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Chromosome fusions and other molecular changes in cells of late generation telomerase-null mutant animals or plants result in a plethora of phenotypes.
The reported associations with plethora of phenotypes (including cancer, autoimmune, cardiovascular, metabolic, and renal and many other diseases) have been extensively meta-analysed and reviewed [ 9, 10].
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This approach has been used to address diverse biological questions and identify a plethora of quantitative phenotypes of varying complexity in numerous different model systems.
Clinical haplotypes, tightly-linked collections of inherited alleles, that are responsible for a plethora of medical phenotypes including patient drug response are important in many medical sequencing applications.
In contrast, a plethora of mouse genetic phenotypes are available but have never been systematically examined before.
miRNAs are small non-coding RNA species which primarily negatively regulate gene expression, thus affecting a plethora of cancer-associated phenotypes.
This may create a plethora of distinct and overlapping phenotypes in several tissues.
Mild loss of function mutations, duplications, and expression level alterations has also been found in patients with a plethora of neurological and mental phenotypes [ 3- 6].
A plethora of electrical, ionic and biochemical phenotypes characterises the myocardium of the STZ-induced diabetic rat.
Along these lines, Sirt3 has been reported to prevent detrimental oxidative-stress-related phenotypes in a plethora of settings, including cardiac hypertrophy, age-related hearing loss and ROS-induced embryonic developmental arrest [ 18, 33, 36].
In order to begin to characterize the range of likely cellular phenotypes caused by this plethora of new candidate anti-macrophage factors we focused on the four positive clusters diagrammed in Figure 3.
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