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In line with the notion that regulated cell death (be it apoptotic or necrotic) is under the control of a plethora of checkpoints and safeguard mechanisms, post-target CDDP resistance may develop along with a wide panel of alterations in the systems that detect the molecular damage caused by CDDP and convert it into a lethal signal, as well as in the machinery that de facto executes cell death.
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Shorter checkpoint intervals cause frequent checkpointing, large number of checkpoints thus resulting in much time spent in checkpoint activity, higher disk space required to store checkpoint images.
Constraint C5 specifies the range on the number of checkpoints.
With lots of checkpoints.
Thereby, TAX triggers a plethora of cell-signalling pathways, reprograms the cell cycle, interferes with checkpoint control and inhibits DNA repair.
"Plethora", for a plethora of reasons.
A plethora of sponsors has pulled out.
Adequate capital hides a plethora of sins.
There is, instead, a plethora of paths.
Nigeria offered a plethora of outstanding books.
"I've got a plethora of problems.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com