It has been suggested that the cluster of SVs within the synapse binds to and buffers a plethora of soluble binding partners of SVs, including proteins involved in exo- and endocytosis (Shupliakov, 2009; Denker et al, 2011a, 2011b).
A plethora of potential binding targets has been identified, including cytoskeletal components such as actin and myosin, and proteins linked to acquired neurodegenerative diseases such as synuclein, tau and β-amyloid [4], [17], [18].
Cell motility is driven by remodeling of the actin cytoskeleton and cell contacts with the extracellular matrix (ECM) [1], a process which is under the control of a plethora of actin-binding proteins.
Moreover, we found CUGBP1 associates with the transcripts encoding a plethora of RNA-binding proteins including several splicing factors as well as PABPN1, PABPC4, HuR(ElavL1) and Pum1 (Dataset S2).
This panel of mutants displays a plethora of NGL-binding properties, summarized and discussed in Supplementary Figure S8.
Tropomyosins contribute to the spatial and temporal regulation of the actin cytoskeleton in an isoform-specific manner, by regulating actin's association with a plethora of actin-binding proteins [ 34].
Following this initial discovery, research has unearthed a plethora of LexA-binding motifs in different bacterial groups, ranging from a GTTC-N7-GTTC direct repeat in the α-Proteobacteria to a TTAC-N3-GTAA palindrome in Bdellovibrio bacteriovorus [ 47, 48].
