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For a more comprehensive description of the theoretical background governing the main findings presented below, please see Methods - Theoretical Background Related to Hydraulic Forces.
All experiments were performed on an Intel core i7 860 with 16 GB of memory, for further details please see Methods section below.
All models, with the exception of the timed runs, were trained and validated on the EBI cluster, for further details please see Methods section below.
For details regarding OPLS-DA please see Methods S1 and Figures S3 and S4 [25].
Please, see Methods for more details.
(For detailed inclusion and exclusion criteria, please see Methods).
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If you have done bad things, please see method #2.
For details of each method, please see the Methods chapter of the Proceedings volume (Tada et al. 2015d).
For additional experimental details, please see the Methods section.
When interrogated using the Gene Set Enrichment Analysis (GSEA) software based on curated datasets (for details please see Online Methods), we identified downregulation of "OL signature" genes, and up-regulation of "P53-pathway" genes (Fig. 4b, c).
In this case however, we replace the conventional area detector with a HEXITEC hyperspectral detector which can record the absorption spectrum in each pixel with an energy resolution of less than 1 keV over the range of 10 100 keV17 (for more information on the detector, please see the methods section).
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