Sentence examples for player in the effect from inspiring English sources

Among these, PARK7/DJ-1 protein levels were induced up to 3 times and this event was associated with the activation of the pro-survival Akt pathway that we propose as a novel player in the effect of N-BPs on osteocytes.

An important downstream player in the effects of metabolic flexibility is the mitochondrion.

In this context, an increase of Akt expression could be a key player in the Warburg effect induction (aerobic glycolysis).

Mechanistically, UCA1 exerts its role in glycolysis by upregulation of HK2, a key glycolytic enzyme and pivotal player in the Warburg effect.

While analysis of C-reactive protein indicates that inflammation is a main player in the additional effect observed, no further cytokine analysis was performed.

Overall, these findings suggest that SCD-1 is a crucial player in the mitogenic effect of estrogen and supports the premise that SCD-1 is a therapeutic target in ERα + ve breast cancer.

Our results corroborate this previous proposal in the context of S. pneumoniae biofilms, clearly identifying the phage activated lytic machinery as a key player in this effect.

Our analysis indicated an unusual distribution of coexpressed neighbors on chromosomes along with an absence of overrepresentation of any biological function in co-expressed neighbors; both these observations are in accordance with the hypothesis that chromatin structure is the key player in the local coexpression effect.

Further research is needed to determine whether miRNAs are key players in the neuroprotective effects of cooling.

He later described an acquired defect in interleukin (IL -2 productIL -2n T1D production46), poinT1Dg at a patientsthat over 20 years later would emerge as a major player in the disease pathogenesis through the effects of IL-2 on regulatory T cells.

To determine whether NOTCH1 is responsible for the inhibition of growth and EMT, we silenced NOTCH1 with siRNA and obtained similar results, revealing that NOTCH1 is an important player in the Pso-induced anticancer effects in BSCSs.