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The major player in response to DSBs is ATM (ataxia telangiectasia mutated).
The Activator Protein-1 (AP-1) transcription factor is a key player in response to extracellular signals, including cytokines [10].
The major player in response to DSBs is ATM (ataxia telangiectasia mutated), which belongs to the PIKK (phosphoinositide 3-kinase related kinase) family of protein kinases [23], [24].
While Pap1 is found to be a redox sensor to low levels of H2O2 (e.g., ∼0.05mM H2O2) and could function independent of Sty1, Atf1 is a major player in response to high levels of H2O2-induced stress (e.g., ∼0.5mM H2O2) [28] [30].
Since SigH was found to be a major player in response to heat shock and oxidative stress, a regulatory network integrating the sigma factors SigH, SigB and SigM is apparently operative in C. glutamicum.
Autophagy, an important homeostatic cellular recycling mechanism, is now emerging as a crucial player in response to metabolic and therapeutic stresses, which attempts to maintain/restore metabolic homeostasis through the catabolic lysis of excessive or unnecessary proteins and injured or aged organelles.
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In vivo models of hypoxia/reperfusion also implicate STAT5 as a player in responses to cellular stress.
Surface electromyography (EMG) recorded long latency reflex times of the medial and lateral quadriceps, hamstring and gastrocnemius muscles in 64 intercollegiate lacrosse and soccer players in response to both internal and external rotation perturbation.
Recent studies have shown that miRNAs are important players in response to bacterial and viral infections in animals and plants [ 8, 15].
"The stupidity comes from where we least expect it," the player said in response.
Also microglia is suggested to be an important player in complex response of nervous tissue to the chronic damage, principally by the activation of cascade of the immune response.
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