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Most of the proteins do not carry out their functions alone, but often form macromolecular complexes to play their functional roles [ 10].
However, they are insufficient to reveal the biological significance of AARs, as proteins play their functional roles by folding into particular secondary and tertiary structures, which are difficult to deduce through amino acid patterns at sequence level.
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Proteins play their biological roles through functional sites, and an alteration in or near a functional site is more likely to disturb the normal function than alterations at other sites.
Besides, the traditional reverse genetics, such as over-expression and RNAi, as well as the lately popular CRISPR/cas9 genome editing technology [133], may also play their roles in promoting functional analysis.
Agent duties are specified in an interaction model and describe the roles that agents can play to fulfil their functional responsibilities.
Second, an assembly/disassembly cycle of eisosomes may play role in their functional properties, yet be locally restricted so that under normal growth conditions only a few eisosomes in the cell are affected at any one time.
In addition, various single nucleotide polymorphisms (SNP's) in other ADH's and ALDH's such as the ADH7 involved in early metabolism of alcohol in the stomach mucosa and the class I ALDH1b1 (previously named as ALDHX and ALDH5) may also play a role, although their functional relevance and clinical importance is unknown [17], [27].
Therefore the amino acid sequences, length and conformation of the loops play important role in their functional specificity (for reviews see [ 53, 55].
The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expreshowinghowing that epigenetic mechanisms play a functional role in their transcriptional control.
The widespread occurrence of these virus-like elements in arthropod genomes suggests that they may play some functional role in their hosts, especially for those types that are transmitted via the genome only.
CNSs differ from other genomic sequences in their nucleotide composition and must play important functional roles, which mostly remain obscure.
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CEO of Professional Science Editing for Scientists @ prosciediting.com