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Increased evidences now indicate that lncRNAs play irreplaceable roles in the establishment of three-dimensional chromatin network (Quinodoz and Guttman, 2014; Rinn and Guttman, 2014).
Some metals, such as copper and iron, are essential to life and play irreplaceable roles in, for example, the functioning of critical enzyme systems but even at trace levels of exposure may cause serious poisoning involving the nervous system and other organs including the skin (Martin and Griswold 2009; Mukeshi et al. 2008).
I remember back in the day, they used to play "Irreplaceable" in the club: "To the left, to the left, everything you own in a box to the left".
Our results suggest that KEGG enrichment scores, subcellular locations, polarity, amino acids composition, hydrophobicity, secondary structure propensity, and number of protein complexes, play irreplaceable roles for protein's metabolic stability.
The publicly available data are not sufficient for elucidating the molecular mechanisms controlling the traits of interest, and moreover, with traditional methods sequencing of these randomly selected cDNA clones from various tissues often has insufficient coverage of less-abundant transcripts, which usually play irreplaceable functions.
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Each of them has its unique structural characters and physicochemical properties, and plays irreplaceable role in biochemistry and biological functions of proteins.
As in the previous example, the production-controller dichotomy structure guarantees the normal functioning of a cell regulation network with both parts playing irreplaceable roles.
Our studies play an irreplaceable role in this work.
Modern cryptographic algorithms play an irreplaceable role in data communication systems for various areas of applications.
Fluorine-containing refrigerants will still play an irreplaceable role in the process of research and development of new refrigerants.
Furthermore, there is an important relation for the second order operator, which will play an irreplaceable role in the analysis of the stability and convergence for our scheme.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com