We are currently investigating the importance of the different residues in the interaction between Evasin-1 and CCL3, and the role this plays in the selectivity of Evasin-1, by site-directed mutagenesis of both partners.
The compartmentalization of caspases, the duration of the caspase signal, or the coordinated expression of antiapoptotic molecules might play a role in the selectivity of caspase cleavage.
Additionally, regions beyond the RBDs of RGS14, e.g., the RGS domain and GoLoco motif, may play a role in the selectivity of RGS14 for activated H-Ras in cells.
Clearly, the position of nitrogen plays an important role in the selectivity of diazacrown ethers to metal ions in the system involved.
An electrochemical sensor for DA has been constructed based on Fc@DWNTs and a kind of cation exchange membrane, Nafion, which played a key role in the selectivity of the sensor.
Based on the structure of this complex, together with homology modeling based on other nAChR subtypes and binding affinity assays, we conclude that Asp-11 of LvIA plays an important role in the selectivity of LvIA towards α3β2 and α3/α6β2β3 nAChRs by making a salt bridge with Lys-155 of the rat α3 subunit.
Neither program ranks in the top 30% of programs in the selectivity of its admissions process, or in the top 20% for postgraduate placement.
We particularly focused on the aromatic/arginine selectivity filter residues that have been shown to play significant role in determining the selectivity of the solutes to be transported [ 55]–[ 57].
In StEH1, the change in protonation state of H104 in the E35Q and H300N mutations appears to play a direct role in modulating the selectivity of the enzyme.
Furthermore, iron impurities are shown to play a key role in modulating the selectivity of Rh/SiO2 catalysts toward ethanol.
