We cannot completely discount any of the current competing hypotheses for increased longevity, nor can we discount the role that other genes outside of telomere maintenance may play in increased longevity.
These results demonstrate the central role that catalase and ROS play in the longevity and fecundity of phlebotomine sand flies.
Some studies have addressed the role that mtDNA heteroplasmy may play in promoting longevity [ 15- 18].
Lipid metabolism has a key role to play in human longevity and healthy ageing.
We continue to evaluate these characteristics to better understand the role these factors play in device longevity and potential toxicity.
With younger patients seeking reconstructions and the activity-based demands placed on the arthroplasty construct, consideration of the role that implant characteristics play in arthroplasty longevity is warranted.
As its absence in immune cells correlates with established signs of aging, this leads us to conclude that autophagy may have a major role to play in promoting longevity.
Given the current demographic trends of younger patients seeking reconstructions and the activity-based demands placed on the arthroplasty construct (Kurtz et al. 2009), consideration of the role that implant characteristics play in arthroplasty longevity is warranted.
Genes do play a role in longevity.
