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Previous work suggests that the primary determinant of channel inactivation is the movement of DIVS4 followed by the binding of the DIII-DIV linker to the intracellular side of the channel12,27; however, as the movements of DIII are immobilized by channel inactivation, it may also play a role in the binding of the DIII-DIV linker28.
The observations that ALCAM is also expressed by activated leukocytes and that both ALCAM and CD6 are expressed in the brain suggest that ALCAM-CD6 interactions may play a role in the binding of T and B cells to activated leukocytes, as well as in interactions between cells of the nervous system.
In the case of neutrophils, it may play a role in the binding of neutrophils to activated endothelium and extravasation into inflamed tissues [9], [10], and similar to epithelial cells, may bind extracellular pathogens [8], [11], [12].
Further, a number of MYB recognition sequences in the promoters are postulated to play a role in the binding of MYB15 to the CBF promoters [ 35].
The zinc finger domain in PfMCM6 is also present at its N-terminal region and may play a role in the binding of PfMCM6 to chromatin.
This positively charged surface might play a role in the binding of the enzyme to membrane structures in the process of assembling autophagophores.
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These proteins are known to play a role in the surface binding of Pb2+[ 117].
Frataxin may also play a role in the simple binding and detoxification of iron.
Thus, N-terminus plays a role in the DNA binding of MsDps2.
The hydroxyl moiety's of both residues play a role in formation of the IPP binding site in the wtFPPS.
The CPMV RNA1-encoded 60 kDa nucleotide-binding protein ('60K') plays a role in the formation of these vesicles.
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